Program Pengelolaan Dan Pencegahan Depresi Melalui Pemeriksaan Apolipoprotein A Dan B Pada Kelompok Lanjut Usia
DOI:
https://doi.org/10.59841/jurai.v2i2.1408Keywords:
apolipoprotein, depresi, edukasi, lanjut usia, pencegahanAbstract
Depresi adalah kondisi kesehatan mental yang serius dan sering terjadi yang dapat menyebabkan penurunan kualitas hidup dan berbagai komplikasi kesehatan. Apolipoprotein A dan B diketahui memiliki hubungan dengan depresi, sehingga dalam upaya pencegahan dan pengelolaan depresi pada lansia, perlu dilakukan skrining apolipoprotein A dan B. Maka dari itu kegiatan pengabdian masyarakat ini dilaksanakan dengan menggunakan metode PDCA (Plan, Do, Check, Act) untuk memastikan keberlangsungan kegiatan ini dan meningkatkan kualitas kegiatan dengan evaluasi berkelanjutan. Kegiatan ini dilaksanakan dengan edukasi kesehatan mengenai pentingnya nutrisi dan aktivitas fisik, serta dukungan sosial. Hasil menunjukkan bahwa pada lansia, didapatkan kadar apolipoprotein A rata-rata adalah 155.59 mg/dL dan apolipoprotein B rata-rata adalah 93.2 mg/dL. Sebanyak 59.1% lansia tidak mengalami depresi, sementara 20.4% mengalami depresi ringan, 9.7% depresi sedang, dan 10.8% depresi berat. Deteksi dini merupakan hal yang penting sehingga individu dapat mencari yang tepat dapat membantu mengelola kadar apolipoprotein, mengurangi risiko depresi, dan pada akhirnya meningkatkan kualitas hidup lansia.
References
Aslam, M. Muaaz, Kang Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E. Snitz, Steven T. DeKosky, Oscar L. Lopez, Eleanor Feingold, and M. Ilyas Kamboh. 2023. “Genome-Wide Analysis Identifies Novel Loci Influencing Plasma Apolipoprotein E Concentration and Alzheimer’s Disease Risk.” Molecular Psychiatry 28, no. 10 (October): 4451–62. https://doi.org/10.1038/s41380-023-02170-4.
Eich, Teal S., Angeliki Tsapanou, and Yaakov Stern. 2019. “When Time’s Arrow Doesn’t Bend: APOE-Ε4 Influences Episodic Memory before Old Age.” Neuropsychologia 133, no. October (October). https://doi.org/10.1016/j.neuropsychologia.2019.107180.
Elnahas, Heba G, Inas T E Sayed, and Marwa M Ahmed. 2021. “Relation Between Depression and Dyslipidemia in Geriatric Patients Attending Family Medicine Outpatients Clinics, Kasralainy Hospital: A Cross Sectional Study.” The Egyptian Family Medicine Journal 5, no. 1: 116–24. https://doi.org/10.21608/efmj.2021.31729.1032.
Elnahas, Heba G, Inas T El Sayed, and Marwa Mostafa Ahmed. 2021. “Relation Between Depression and Dyslipidemia in Geriatric Patients Attending Family Medicine Outpatients Clinics, Kasralainy Hospital: A Cross Sectional Study.” The Egyptian Family Medicine Journal. https://doi.org/10.21608/efmj.2021.31729.1032.
Fan, Jialing, Wuhai Tao, Xin Li, He Li, Junying Zhang, Dongfeng Wei, Yaojing Chen, and Zhanjun Zhang. 2019. “The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk.” International Journal of Molecular Sciences 20, no. 5 (March). https://doi.org/10.3390/ijms20051177.
Feingold, Kenneth R. 2022. “Lipid and Lipoprotein Metabolism.” Endocrinology and Metabolism Clinics of North America 51, no. 3 (September): 437–58. https://doi.org/10.1016/j.ecl.2022.02.008.
Firmansyah, Y, and G Widjaja. 2022. “Masalah-Masalah Dalam Kesehatan Jiwa.” Journal Cross-Border 5, no. 1: 474–502. http://journal.iaisambas.ac.id/index.php/Cross-Border/article/view/1100.
Firmansyah, Yohanes, and Imam Haryanto. 2021. “Psycho-Socio-Juridic Review Of Lockdown And Work From Home Policies On Psychological Symptoms In Productive Groups And Strategic Solutions Of National Economy.” Ganaya : Jurnal Ilmu Sosial Dan Humaniora 4, no. 2 (September): 531–51. https://doi.org/10.37329/ganaya.v4i2.1347.
Firmansyah, Yohanes, Ernawati Su, Ivan Buntara, Hendsun Hendsun, Fiolita Indranita Sutjipto, and Pinka Nurashri Setiyati. 2020. “Uji Kesahihan Interna Dan Kehandalan Kuesioner Cabin Fever Phenomenon (Cfp) Versi Indonesia.” Jurnal Muara Sains, Teknologi, Kedokteran Dan Ilmu Kesehatan 4, no. 2 (October): 443. https://doi.org/10.24912/jmstkik.v4i2.8456.
Gharbi-Meliani, Amin, Aline Dugravot, Séverine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimäki, Archana Singh-Manoux, and Julien Dumurgier. 2021. “The Association of APOE Ε4 with Cognitive Function over the Adult Life Course and Incidence of Dementia: 20 Years Follow-up of the Whitehall II Study.” Alzheimer’s Research and Therapy 13, no. 1 (December). https://doi.org/10.1186/s13195-020-00740-0.
Giammanco, Antonina, Rossella Spina, Angelo B Cefalù, and Maurizio Averna. 2023. “APOC-III: A Gatekeeper in Controlling Triglyceride Metabolism.” Current Atherosclerosis Reports 25, no. 3 (March): 67–76. https://doi.org/10.1007/s11883-023-01080-8.
Gong, Jessica, Katie Harris, Sanne A.E. Peters, and Mark Woodward. 2022. “Serum Lipid Traits and the Risk of Dementia: A Cohort Study of 254,575 Women and 214,891 Men in the UK Biobank.” EClinicalMedicine 54, no. December (December). https://doi.org/10.1016/J.ECLINM.2022.101695.
Greenberg, S. A. 2019. “The Geriatric Depression Scale (GDS) Validation of a Geriatric Depression Screening Scale: A Preliminary Report.” Best Practices in Nursing Care to Older Adults, no. 4: 2.
Hawari, I, DA Wijaya, F Nathaniel, and NS Tadjudin. 2023. “Hubungan Depresi Dengan Kejadian Gangguan Kognitif.” J of Educational Innovation & Public Health 1, no. 3: 75–85.
Huang, Chun Hsien, Yun Fu, and Ching Chi Chi. 2021. “Health-Related Quality of Life, Depression, and Self-Esteem in Patients with Androgenetic Alopecia: A Systematic Review and Meta-Analysis.” JAMA Dermatology 157, no. 8 (August): 963–70. https://doi.org/10.1001/JAMADERMATOL.2021.2196.
Ikanga, Jean, Saranya Sundaram Patel, Blaine R Roberts, Megan Schwinne, Sabrina Hickle, Inge M W Verberk, Emmanuel Epenge, et al. 2023. “Association of Plasma Biomarkers with Cognitive Function in Persons with Dementia and Cognitively Healthy in the Democratic Republic of Congo.” Alzheimer’s & Dementia (Amsterdam, Netherlands) 15, no. 4 (October): e12496. https://doi.org/10.1002/dad2.12496.
Johnson, Adiv A, and Alexandra Stolzing. 2019. “The Role of Lipid Metabolism in Aging, Lifespan Regulation, and Age-Related Disease.” Aging Cell 18, no. 6 (December): e13048. https://doi.org/10.1111/acel.13048.
Joshi, Rinku Gautam, Arun K Pandey, Nidesh Sapkota, Rajesh Kumar, Prashant Shah, Robin Maskey, and Vivek Kattel. 2018. “Burden of Thyroid and Lipid Disorders Among Elderly Depressed Patient: A Cross Sectional Study in Nepal.” Journal of Diabetes and Endocrine Association of Nepal. https://doi.org/10.3126/jdean.v2i2.22360.
Kim, Young Ho, and Jeana Hong. 2019. “The Association Between Depressive Mood and Cholesterol Levels in Korean Adolescents.” Psychiatry Investigation. https://doi.org/10.30773/pi.2019.03.24.
Klímová, Blanka, Miroslav Novotný, and Martin Vališ. 2020. “The Impact of Nutrition and Intestinal Microbiome on Elderly Depression—A Systematic Review.” Nutrients 12, no. 3: 710. https://doi.org/10.3390/nu12030710.
Kumar, Abhishek, Dilip Raj, Atul Gupta, and Amit Kumar. 2021. “Screening of Depression in Elderly Population Using a Geriatric Depression Scale in the Field Practice Area of Urban Health Training Centre Attached to SMS Medical College, Jaipur.” Cureus. https://doi.org/10.7759/cureus.15859.
Li, Bozhi, Yue Qu, Zhixin Fan, Xiayu Gong, Hanfang Xu, Lili Wu, and Can Yan. 2023. “Causal Relationships between Blood Lipids and Major Psychiatric Disorders: Univariable and Multivariable Mendelian Randomization Analysis.” BMC Medical Genomics 16, no. 1 (December). https://doi.org/10.1186/s12920-023-01692-8.
Li, Lin-yi, Shu-fen Liu, Jian-long Zhuang, Mi-mi Li, Zheng-ping Huang, Yan-hong Chen, Xiang-rong Chen, Chun-nuan Chen, Shu Lin, and Li-chao Ye. 2023. “Recent Research Progress on Metabolic Syndrome and Risk of Parkinson’s Disease.” Reviews in the Neurosciences 34, no. 7 (October): 719–35. https://doi.org/10.1515/revneuro-2022-0093.
Nekar, Manjunath S, Anjana Joshi, and Dattatraya D Bant. 2022. “Geriatric Depression and Its Association With Geriatric Malnutrition: A Cross-Sectional Study in Hubballi, North Karnataka.” National Journal of Community Medicine. https://doi.org/10.55489/njcm.1332022388.
Park, Ji Eun, and Ryoung Choi. 2022. “Factors Related to Depression and Mental Health That Affect the Quality of Life of the Elderly.” Journal of Environmental and Public Health. https://doi.org/10.1155/2022/7764745.
Putri, Hasna R, and Triska S Nindya. 2019. “Ubungan Kecenderungan Depresi Dengan Status Gizi Pada Lansia Di Uptd Griya Werdha Surabaya.” Media Gizi Indonesia 14, no. 1: 87. https://doi.org/10.20473/mgi.v14i1.87-94.
Rasmussen, Katrine L, and Ruth Frikke-Schmidt. 2024. “The Current State of Apolipoprotein E in Dyslipidemia.” Current Opinion in Lipidology 35, no. 2 (April): 78–84. https://doi.org/10.1097/MOL.0000000000000915.
Riedel, Brandalyn C., Paul M. Thompson, and Roberta Diaz Brinton. 2016. “Age, APOE and Sex: Triad of Risk of Alzheimer’s Disease.” Journal of Steroid Biochemistry and Molecular Biology 160, no. June (June): 134–47. https://doi.org/10.1016/j.jsbmb.2016.03.012.
Rosada, Adrian, Ursula Kassner, Felix Weidemann, Maximilian König, Nikolaus Buchmann, Elisabeth Steinhagen-Thiessen, and Dominik Spira. 2020. “Hyperlipidemias in Elderly Patients: Results from the Berlin Aging Study II (BASEII), a Cross-Sectional Study.” Lipids in Health and Disease 19, no. 1 (May): 92. https://doi.org/10.1186/s12944-020-01277-9.
Rosenson, Robert S, H Bryan Brewer, Benjamin J Ansell, Philip Barter, M John Chapman, Jay W Heinecke, Anatol Kontush, Alan R Tall, and Nancy R Webb. 2016. “Dysfunctional HDL and Atherosclerotic Cardiovascular Disease.” Nature Reviews. Cardiology 13, no. 1 (January): 48–60. https://doi.org/10.1038/nrcardio.2015.124.
Sadeghi, Ahmad, Hasan Jafari, Hossein Rouhani, Fereshteh Eidy, Akram Zhiani Fard, and Najmeh Davoodi. 2020. “Relationship Between Nutritional Status and Late-Life Depression in Esfarayen, Iran.” Elderly Health Journal. https://doi.org/10.18502/ehj.v6i1.3412.
Sadeghi, Masoumeh, Hamidreza Roohafza, Hamid Afshar, Fereshteh Rajabi, Mohamadarash Ramzani, Hasan Shemirani, and Nizal Sarafzadeghan. 2011. “Relationship between Depression and Apolipoproteins A and B: A Case–control Study.” Clinics 66, no. 1 (January): 113–17. https://doi.org/10.1590/S1807-59322011000100020.
Sayed, Naila N. 2023. “Social Isolation and Depression and Its Predictors Among Elderly of the Urban Field Practice Area of a Medical College: A Community-Based Cross-Sectional Study.” Journal of the Indian Academy of Geriatrics. https://doi.org/10.4103/jiag.jiag_52_23.
Vidyalakshmi, M, and B Kirubhakaran. 2021. “Assessment of Nutritional Status and Its Associated Factors in Elderly in Rural Area of Tamil Nadu, India.” Galore International Journal of Health Sciences and Research 6, no. 1: 38–43. https://doi.org/10.52403/gijhsr.20210107.
Xu, Yuexuan, Zhongxuan Sun, Erin Jonaitis, Yuetiva Deming, Qiongshi Lu, Sterling C. Johnson, and Corinne D. Engelman. 2024. “Apolipoprotein E Moderates the Association between Non-APOE Polygenic Risk Score for Alzheimer’s Disease and Aging on Preclinical Cognitive Function.” Alzheimer’s and Dementia 20, no. 2 (February): 1063–75. https://doi.org/10.1002/alz.13515.
Zeng, Yanfang, Wenying Du, Mingkai Zhang, Ariel Walker, Ying Han, and Yuchuan Ding. 2024. “APOEε4 Carriers Exhibit Objective Cognitive Deficits: A Cross-Sectional Study in a Single Center Trial.” Brain Sciences 14, no. 3 (March). https://doi.org/10.3390/brainsci14030281.
Zhou, Zhen, Joanne Ryan, Andrew M. Tonkin, Sophia Zoungas, Paul Lacaze, Rory Wolfe, Suzanne G. Orchard, et al. 2023. “Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults.” Neurology 101, no. 22 (November). https://doi.org/10.1212/WNL.0000000000207923.
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