Pengaruh eksipien terhadap sifat fisik granul effervescent : Review

Authors

  • Reza Pratama Universitas Bhakti Kencana
  • Munir Alinu Mulki Fakultas Ilmu Kesehatan, Universitas Singaperbangsa
  • M. Ramadhan Saputro Universitas Bhakti Kencana
  • Afifah Rusyda Sani Universitas Bhakti Kencana
  • Ratu Siti Robiatul Awaliyah Universitas Bhakti Kencana

DOI:

https://doi.org/10.59841/an-najat.v2i1.1071

Keywords:

Formulation, Evaluation, Effervescent Granule, Plant Extracts

Abstract

The use of various plant species, which are then formulated using pharmaceutical technology in the form of effervescent granule preparations, is a strategy to increase the practicality and public interest in consuming herbal medicines. The natural ingredients most commonly used as the main ingredients in the manufacture of effervescent granules include fruits, rhizomes, fruit peels, leaves and seeds. Effervescent granules are a mixture of acidic and alkaline compounds which, when added to water, produce a carbon dioxide reaction. This creates a foam that gives a fresh taste effect and can mask unwanted flavours. The purpose of this article is to provide information on the formulation and evaluation of effervescent granules from various plant extracts that may have public health benefits. The method used to collect the data was a search of several journals. The results of the search showed the influence of excipients on the physical properties of the granules. These include organoleptic properties, flow time, dissolution time, water content and pH of effervescent granule preparations.

 

References

A. Anugra Diputra, H. Latifah, dan M. Fuji Rahayu, “FORMULATION AND PHYSICAL EVALUATION OF EFFERVESCENT GRANULES OF MINT LEAF EXTRACT (Mentha x piperita L) AS STIMULANSIA,” 2023.

A. Dewangga, S. Fatimah Meirani, R. Apriliany, U. Afrinurfadhilah Darojati, dan dan Awan Indra Yudha, “FORMULASI TABLET EFFERVECENT DARI EKSTRAK ETANOL DAUN TALAS (Colocasia esculenta L.) SEBAGAI ANTISEPTIK TOPIKAL EFFERVESCENT TABLETS FORMULATION OF TALAS (Colocasia esculenta L.) LEAVES ETHANOL EXTRACT OF AS A TOPICAL ANTISEPTIC,” 2017.

A. Khalda Soraya, B. Sindi, dan A. Naadiah, “FORMULASI GRANUL EFFERVESCENT ANTI DIABET EKSTRAK KULIT BUAH ASAM JAWA (Tamarindus indica),” 2023.

C. Lynatra, Y. Elisya, dan Wardiansyah, “FORMULATION OF EFFERVESCENT TABLET OF TEMULAWAK EXTRACT (Curcuma xanthorrhiza Roxb.) WITH VARIATION OF STEVIA AS SWEETENER,” JURNAL TEKNOLOGI DAN SENI KESEHATAN, vol. 09, 2018.

D. A. Oktavia, D. Fithriani, dan P. Martosuyono, “Physical Characteristics of Probiotic Effervescent Tablets with Various Concentration of Maltodextrin as Coating Materials,” dalam E3S Web of Conferences, EDP Sciences, Feb 2020. doi: 10.1051/e3sconf/202014703023.

D. F. Puspitasari, R. Suharsanti, S. Yayasan, P. Semarang, dan P. Pertama, “Formulasi Granul Effervescent Ekstrak Etanol Buah Gowok (SYZGIUM POLYCEPHALUM Merr),” 2022.

D. Forestryana, Y. Hestiarini, dan A. N. Putri, “FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL 90% BUAH LABU AIR (Lagenaria siceraria) SEBAGAI ANTIOKSIDAN DENGAN VARIASI GAS GENERATING AGENT,” Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan, vol. 5, no. 2, hlm. 220–229, Okt 2020, doi: 10.36387/jiis.v5i2.457.

D. J. S. Putra, “Penggunaan Polivinill Pirolidon (PVP) Sebagai Bahan Pengikat Pada Formulasi Tablet Ekstrak Daun Sirih (Piper betle L.),” Jurnal Farmasi Udayana, hlm. 14, Jul 2019, doi: 10.24843/jfu.2019.v08.i01.p03.

D. Nurahmanto, M. Irine Prabandari, dan B. Triatmoko, “OPTIMASI FORMULA GRANUL EFFERVESCENT KOMBINASI EKSTRAK KELOPAK BUNGA Hibiscus sabdariffa L. DAN EKSTRAK DAUN Guazuma ulmifolia Lam.,” PHARMACY, vol. 14, 2017.

D. R. Basuki, “Formulation and Characterisation of Granule Effervescent Cilembu Sweet Potato(Ipomoea batatas (L). Lamk)Extract With Concentration Variation of Citric Acid and Sodium Bicarbonate,” 2015.

E. S. Syamsul dan Supomo, “FORMULATION OF EFFERVESCENT POWDER OF WATER EXTRACT OF BAWANG TIWAI (Eleuterine palmifolia) AS A HEALTHY DRINK,” Traditional Medicine Journal, vol. 19, no. 3, hlm., 2014.

F. F. Sriarumtias, N. Rantika, dan A. S. Rohmah, “Formulasi Granul Effervescent Ekstrak Pandan Laut (Pandanus tectorius Parkinson ex Du Roi) Sebagai Analgetik (Effervescent Granule Formulation of Sea Pandan Extract (Pandanus tectorius Parkinson ex Du Roi) as Analgesic),” Pharmauho: Jurnal Farmasi, vol. 6, no. 2, hlm. 60–66, 2020, doi: 10.33772/pharmauho.

F. Gustaman, K. Idacahyati, dan W. T. Wulandari, “Formulation and evaluation of kirinyuh leaf effervescent granules (Chromolaena odorata. L) as an antioxidant,” Pharmacy Education, vol. 21, no. 2, hlm. 123–125, Jul 2021, doi: 10.46542/pe.2021.212.123125.

F. Gustaman, N. Rahayuningsih, dan S. H. Octavani, “Studi Aktivitas Antioksidan Sediaan Granul Effervescent Daun Kirinyuh (Chromolaena odorata (L.) R.M.King & H.Rob) dan Daun Salam (Syzygium polyanthum (Wight) Walp.),” 2022.

F. N. Syaputri, S. Zulfa Saila, T. Daru, A. Tugon, A. Puji, dan D. Lestari, “Formulasi dan Uji Karakteristik Fisik Sediaan Granul Effervescent Ekstrak Etanol Daun Sirih Merah (Piper crocatum ruiz & pav.) Sebagai Antidiabetes,” Jurnal Ilmu Kefarmasian, vol. 4, 2023.

F. S. Masitha dan R. Febriansah, “Antioxidant Activity from the Combination of Ethanolic Extract of Tea Leaves (Camellia sinensis) and Soursop Leaves (Annona muricata l.) and Optimation of the Effervescent Granule Production,” Mutiara Medika: Jurnal Kedokteran dan Kesehatan, vol. 19, no. 2, 2019, doi: 10.18196/mm.190230.

H. Fathi, A. Davoodi, H. B. Jouybari, dan P. Ebrahimnejad, “FORMULATION AND PHYSICOCHEMICAL EVALUATION OF MEDLAR (MESPILUS GERMANICA L.) AND OAK (QUERCUS CASTANEIFOLIA C. A. MEY.) EFFERVESCENT TABLETS,” Article in International Journal of Research in Pharmaceutical Sciences, vol. 9, no. 9, hlm. 3870–3875, 2018, doi: 10.13040/IJPSR.0975-8232.9(9).3870-75.

I. B. Grajang dan I. Wahyuningsih, “Formulation of Sechium edule Extract Effervescent Granule with the Variation of Citric Acid, Tartrate Acid and Sodium Bicarbonate,” Scitepress, Jun 2019, hlm. 54–60. doi: 10.5220/0008239300540060.

I. F. Rahmawati, P. Pribadi, dan I. W. Hidayat, “Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.),” Pharmaciana, vol. 6, no. 2, Okt 2016, doi: 10.12928/pharmaciana.v6i2.4078.

I. Gusmayadi, M. Lestari, E. Trisnande, dan J. Farmasi, “VARIASI KONSENTRASI ASAM SITRAT SEBAGAI SUMBER ASAM TERHADAP SIFAT FISIK TABLET EFFERVESCENT EKSTRAK KERING KULIT BUAH MANGGIS (Garcinia mangostana L),” 2016.

Indarto dan K. Puspitasary, “PENGARUH VARIASI KADAR ASAM BASA TERHADAP WAKTU LARUT GRANUL EFFERVESCENT EKSTRAK HERBA MENIRAN (PHYLLANTHUS NIRURI L),” Jurnal Health Sains, vol. 3, 2022, doi: 10.46799/Jhs.V3i7.530.

M. Indriastuti, A. Fuji Astuti, A. L. Yusuf, F. Akbar, dan K. S. R. Rahmah, “OPTIMASI FORMULA SEDIAAN GRANUL EFFERVESCENT EKSTRAK DAUN KELOR (Moringa oleifera L.) FORMULA OPTIMIZATION OF EFFERVESCENT GRANULE OF MORINGA LEAF EXTRACT (Moringa Oleifera L.),” 2023.

M. Mahdiyyah, I. M. Puspitasari, N. A. Putriana, dan M. R. A. A. Syamsunarno, “Review: Formulasi dan Evaluasi Sediaan Oral Effervescent,” Majalah Farmasetika, vol. 5, no. 4, Agu 2020, doi: 10.24198/mfarmasetika.v5i4.27278.

M. Ramadhia dan I. Ichsan, “Pengolahan Lidah Buaya (Aloe Vera) Menjadi Granul Effervescent sebagai Minuman Kesehatan dan Analisis Peningkatan Nilai Ekonomisnya,” Jurnal Ekonomi Bisnis dan Kewirausahaan, vol. 7, no. 2, hlm. 149, Agu 2018, doi: 10.26418/jebik.v7i2.25991.

N. A. Lobubun dan L. Chabib, “Formulasi Granul Effervescent Ekstrak Aseton Rimpang Kencur (Kaempferia Galanga L.) dengan Variasi Konsentrasi Polivinilpirolidon,” Journal of Pharmaceutical and Health Research, vol. 3, no. 3, hlm. 139–149, 2022, doi: 10.47065/jharma.v3i3.2922.

N. Hasyim dan dan Zahriati, “FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava LINN),” 2013.

N. Lubis, R. Prasetiawati, dan G. Rahmat, “Formulasi, Evaluasi, dan Perbandingan Intensitas Kepedasan Granul Effervescent Jahe,” 2016.

N. M. D. S. Suene, I. G. M. Suradnyana, dan Rr. A. Juanita, “Formulasi dan Uji Aktivitas Antioksidan Granul Effervescent dari Kombinasi Ekstrak Kunyit Putih (Curcuma Zedoaria) dan Kunyit Kuning (Curcuma Longa L.),” Jurnal Ilmiah Medicamento, vol. 7, no. 1, hlm. 27–31, Mar 2021, doi: 10.36733/medicamento.v7i1.1502.

N. M. Putri, N. S. Slamet, P. S. Wicita, dan A. K. Imran, “GRANUL EFFERVESCENT KOMBINASI BUNGA TELANG (Clitoria ternatea) DAN JERUK KALAMANSI (Citrus microcarpa) SEBAGAI ALTERNATIF MINUMAN KESEHATAN,” 2021. [Daring]. Tersedia pada: http://jurnal.poltekkesgorontalo.ac.id/index.php/JECP

N. Zuraidah, W. D. Ayu, dan M. Ardana, “Pengaruh Variasi Konsentrasi Asam Sitrat dan Asam Tartrat terhadap Sifat Fisik Granul Effervescent dari Ekstrak Daun Nangka (Artocarpus heterophyllus L.),” Proceeding of Mulawarman Pharmaceuticals Conferences, vol. 8, hlm. 48–56, Des 2018, doi: 10.25026/mpc.v8i1.302

P. Santoso, D. Juliadi, N. N. W. Udayani, I. P. P. J. Separsa, I. A. G. S. Mahayani, dan I. G. Y. Trismawan, “Skrining Fitokimia, Formulasi dan Antioksidan Sediaan Granul Effervescent Ekstrak N-Butanol Buah Dewandaru (Eugenia uniflora L.),” Malahayati Nursing Journal, vol. 5, no. 2, hlm. 541–555, Feb 2023, doi: 10.33024/mnj.v5i2.7509.

R. D. Astuti dan W. A. Wijaya, “FORMULASI DAN UJI KESTABILAN FISIK GRANUL EFFERVESCENT INFUSA KULIT PUTIH SEMANGKA (Citrullus vulgaris S.) DENGAN KOMBINASI ASAM,” Jurnal Kesehatan, vol. XI, 2016.

R. D. Tedi, M. Taswin, dan S. Simamora, “Potential Granule Effervescent from a mixture of beetroot extract (Beta vulgaris L), Malang apple (Malus sylvestris L.) and Carrot (Daucus carota L.) as Preparation for Lowering Blood Cholesterol Levels,” 2022. [Daring]. Tersedia pada: www.ijisrt.com

R. Dewi, Iskandarsyah, dan D. Octarina, “Tablet Effervescent Ekstrak Belimbing Wuluh (Averrhoa bilimbi L.),” Journal Pharm Sci Res, 2014.

R. Pratama, D. P. Azhary, S. Muhsinin, dan A. Khumairani, “FORMULATION AND EVALUATION OF EFFERVESCENT GRANULE OF WHITE TEMU RHIZOME EXTRACT (Curcuma zedoaria (Christm.) Roscoe.) AS ANTIOXIDANT,” 2023.

R. Rachmaniar, H. Kartamihardja, “PEMANFAATAN SARI BUAH JAMBU BIJI MERAH (Psidium guajava Linn.) SEBAGAI ANTIOKSIDAN DALAM BENTUK GRANUL EFFERVESCENT*,” 2016.

R. Wirdia, “GRANUL EFFERVESCENT EKSTRAK KULIT BAWANG MERAH (Allium cepa L.) SEBAGAI OBAT HERBAL PENGOBATAN INFEKSI BAKTERI Streptococcus pyogenes PENYEBAB FARINGITIS,” 2017.

S. Ashufiah, W. Hajrin, dan S. Ridwan, “TERHADAP SIFAT FISIK GRANUL EFFERVESCENT SARI WORTEL (Daucus carota L),” Journal of Comprehensive science, vol. 2, 2023.

S. Dianengsih dan Herliningsih, “FORMULASI DAN EVALUASI FISIK SEDIAAN GRANUL EFFERVESCENT EKSTRAK TEMU GIRING (Curcuma heyneana Valeton & Zijp),” 2023. [Daring]. Tersedia pada: http://ojs.stikes-muhammadiyahku.ac.id/index.php/herbapharma

S. G. Patel dan M. Siddaiah, “Formulation and evaluation of effervescent tablets: a review,” Journal of Drug Delivery and Therapeutics, vol. 8, no. 6, hlm. 296–303, Nov 2018, doi: 10.22270/jddt.v8i6.2021.

S. Kholidah dan A. Khumaidi, “EFFERVESCENT TABLET FORMULATION GINGER (Z officinale Roscoe) WITH CONCENTRATION VARIATION SOURCES ACID AND BASES,” 2014.

S. Mutiarahma, Y. Budi Pramono, dan Nurwantoro, “Evaluasi Kadar Gula, Kadar Air, Kadar Asam dan pH pada Pembuatan Tablet Effervescent Buah Nangka,” 2018. [Daring]. Tersedia pada: www.ejournal-s1.undip.ac.id/index.php/tekpangan.

S. Surini, M. R. W. Wardani, dan E. Sagita, “Evaluating of effervescent tablets containing grape seed (Vitis vinifera L.) extract as a nutraceutical,” International Journal of Applied Pharmaceutics, vol. 9, hlm. 150–153, Okt 2017, doi: 10.22159/ijap.2017.v9s1.76_83.

S. Wati dan D. Saryanti, “Effervescent Granule Formulation of Bitter Melon Extract (Momordica charantia L.) with Gelatin as A Wet Granulation Binder,” 2019. [Daring]. Tersedia pada: http://journals.ums.ac.id/index.php/jnhm

T. B. Julianti, I. A. Mentari, E. R. Wikantyasning, S. Azzahra, dan I. Hairunisa, “Formulasi dan Uji Antioksidan Formula Granul Effervescent Ekstrak Kulit Buah Pulasan (Nephelium mutabile Blume),” ! 285 Jurnal Pharmascience, vol. 9, no. 2, hlm. 285–299, 2022, [Daring]. Tersedia pada: https://ppjp.ulm.ac.id/journal/index.php/pharmascience

T. Suhesti, Warsinah, dan Pitra Wulandari, “Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant Acta Pharmaciae Indonesia: Acta Pharm Indo,” vol. 10, no. 1, 2022, doi: 10.20884/1.api.2022.10.1.5803.

W. Bin Jamaludin, N. Masytoh, dan E. F. Susiani, “FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN GRANUL EFFERVESCENT DARI KOMBINASI EKSTRAK ETANOL 70% BUNGA ROSELLA (Hibiscus sabdariffa L.) DAN BUNGA TELANG (Clitoria ternatea L.),” Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan, vol. 8, no. 1, hlm. 1–10, Mar 2023, doi: 10.36387/jiis.v8i1.1065.

W. M. Sidoretno, H. Rosaini, I. Makmur, dan F. D. Kharisma, “Formulation and Evalution of Effervescent Granules Combination Extract Red Ginger, Curcuma and Cinnamon,” JOPS (Journal Of Pharmacy and Science), vol. 5, no. 1, hlm. 21–35, 2022.

W. R. Oktavina dan H. N. Imtihani, “Formulasi dan Evaluasi Suspensi Granul Effervescent Ekstrak Kitosan Cangkang Kepiting Bakau (Scylla serrata) Dengan Perbandingan Natrium Bikarbonat,” Journal of Islamic Pharmacy, vol. 8, no. 2, hlm. 62–67, Des 2023, doi: 10.18860/jip.v8i2.23533.

Y. Farida dan H. Rahmadani, “Formulasi Granul Eff ervescent Ekstrak Etanol Buah Andaliman (Zanthoxylum acanthopodium DC.) dengan Variasi Sumber Asam dan Uji Aktivitas Antioksidan,” JURNAL ILMU KEFARMASIAN INDONESIA, vol. 29, no. 2020, hlm. 96–101, 2020.

Y. Hayaza, A. R. Erwiyani, dan J. Susilo, “FORMULASI DAN PENGARUH KONSENTRASI ASAM SITRAT, ASAM TARTRAT DAN NATRIUM BIKARBONAT TERHADAP SIFAT GRANUL EFFERVESCENT EKSTRAK LABU KUNING (Cucurbita maxima Duch),” 2019.

Y. W. Permadi, S. Rahmatullah, L. Dwi Prafitri, dan R. Syifa Azmi Putri, “Effervescent Granule Formulation Of Alpocate Seed Extract (Persea Americana Mill.) With Acid-Basic Concentration Variation,” 2021.

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Published

2024-02-27

How to Cite

Pratama, R., Munir Alinu Mulki, Saputro, M. R., Afifah Rusyda Sani, & Ratu Siti Robiatul Awaliyah. (2024). Pengaruh eksipien terhadap sifat fisik granul effervescent : Review. An-Najat, 2(1), 137–154. https://doi.org/10.59841/an-najat.v2i1.1071

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