Formulasi Sediaan Gummy Candies Analgetic Kombinasi Ekstrak Daun Pepaya (Carica papaya L.) Dan Daun Kelor (Moringa oleifera lam.)

Authors

  • Arifina Fahamsya Universitas Bhamada Slawi
  • Endang Istriningsih Universitas Bhamada Slawi
  • Salsa Adinda Novita Universitas Bhamada Slawi

DOI:

https://doi.org/10.59841/an-najat.v2i3.1539

Keywords:

analgesic, papaya leaf extract & moringa leaf extract, gummy candies

Abstract

Analgesics are drugs that selectively reduce pain by acting in the central nervous system or on peripheral pain mechanisms, without altering consciousness. The types of plants used in medicine are papaya leaves and moringa leaves. Papaya leaves and Moringa leaves contain secondary metabolite compounds; one of them is flavonoids that act as analgesics. The purpose of this study was to determine the combination of papaya leaf extract and Moringa leaves made into gummy candies, to find out the best formulation of the gummy candies. The method in this study was the experimental method. The type of extraction in this study using 70% alcohol solvent. The extract was formulated into gummy candies and conducted evaluation tests including organoleptic, weight uniformity, pH, chewiness, and favorability tests. The organoleptic test results showed that all formulations had a distinctive aroma of brown essence and chewy texture, while the color of formulation 0 was clear yellow. Formulation 1, 2, and 3 were dark brown. Weight uniformity test on all four formulations was no deviated weights. The pH tests of all formulations had the same pH of 6 meaning that met the pH requirements with a range of 5-7. Chewiness tests on all formulations had a range of 4 cm. The condition for the elasticity of gummy candies was that the longer they were, the chewier they were. The results of the hedonic test or favorability test were analyzed using the Kruskal wallis test of each parameter of interest, namely formulation color 0, aroma formulation 1, taste formulation 0, as well as texture formulation 0 and 1.

References

Afrianti, R., Yenti, R., & Meustika, D. (2014). Uji Aktifitas Analgetik Ekstrak Etanol Daun Pepaya (Carica papaya L.) pada Mencit Putih Jantan yang di Induksi Asam Asetat 1%. Jurnal Sains Farmasi & Klinis, 1(1), 54. https://doi.org/10.29208/jsfk.2014.1.1.12.

Ahmad, A. R., Juwita, J., & Ratulangi, S. A. D. (2015). Penetapan Kadar Fenolik dan Flavonoid Total Ekstrak Metanol Buah dan Daun Patikala (Etlingera elatior (Jack) R.M.SM). Pharmaceutical Sciences and Research, 2(1), 1–10. https://doi.org/10.7454/psr.v2i1.3481

Amaria, E. F., & Luliana, S. (2016). Formulasi Sediaan Gummy Candies Ekstrak Herba Pegagan (Centella asiatica) menggunakan pektin dari Daun Cincau Hijau (Cyclea barbata Miers) Gummy Candies formulation of Pegagan Herba Extract (Centella asiatica) using pectin from Green Cincau Leaves. (Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 5(1), 1–9.

Darna, A. R. P., M.L.M Timbuleng, E. M. L. M. T., Azzahroh, N., Khasanah, P. U., Arofah, G. E., & Kartikasari, M. N. D. (2019). PERI DALOR (Permen Jeli Daun Kelor) : Inovasi Permen Kaya Antioksidan Sebagai Solusi Kesehatan. SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, Dan Seni Bagi Masyarakat), 8(1), 35–39. https://doi.org/10.20961/semar.v8i1.22062

Gohel, M. C., Parikh, R. K., Nagori, S. A., & Shah, S. N. (2009). Formulation of reconstitutable gellan gum gel containing paracetamol. Indian Drugs, 46(1), 73–77.

Husni, P., Lestari, M. D., & Hasanah, U. (2020). Formulasi Dan Uji Stabilitas Fisik Chewable Gum Ekstrak Kering Temulawak (Curcuma xanthorrhiza Roxb.) Mengandung Kappa Karagenan. Jurnal Sabdariffarma, 8(2), 22–27. https://doi.org/10.53675/jsfar.v2i2.378

Lina, R. N., & Rahmawaty, A. (2022). Uji Efektivitas Analgesik Kombinasi Ekstrak Etanol Umbi Rumput Teki (Cyperus rotundus L.) dan Daun Kelor (Moringa oleifera Lam.) pada Mencit Jantan dengan Metode Geliat. Cendekia Journal of Pharmacy, 6(1), 55–64. https://doi.org/10.31596/cjp.v6i1.145.

Novriyanti, R., Putri, N., & Rijai, L. (2022). Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Jeruk Nipis (Citrus aurantifolia) Menggunakan Metode DPPH Phytochemical. 27–29.

Putra Pratama I Wayan Dwika , Anak Agung Gde Oka Dharmayudha, L. M. S. (2016). Identifikasi Senyawa Kimia Ekstrak Etanol Daun Kelor (Moringa oleifera L) di Bali. Indonesia Medicus Veterinus Oktober, 5(5), 464–473.

Rashati, D., & Christiningtyas Eryani, M. (2019). Formulasi Dan Uji Stabilitas Gummy Candies Buah Naga (Hylocereus polyrhizus) Dengan Variasi Konsentrasi Gelatin Dan Karagenan Sebagai Gelling Agent Formulation And Stability Test Of Gummy Candies Fruit Dragon (Hylocereus polyrhizus) With Variation Of Gela. Jurnal Informasi Kesehatan Indonesia, 5(2), 58–64.

Rowe, Sheskey, & Quinn. (2009). Handbook of Pharmaceutical Excipients (Sixth Edit). Pharmaceutical Press.

Sentat, T., & Pangestu, S. (2017). Uji Efek Analgesik Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Pada Mencit Putih Jantan (Mus Musculus) Dengan Induksi Nyeri Asam Asetat. Jurnal Ilmiah Manuntung, 2(2), 147–153. https://doi.org/10.51352/jim.v2i2.59

Sunaryo, A. R., Zaky, M., & Rasydy, L. O. A. (2020). Formulasi Nutraseutikal Gummy Candies Sari Buah Belimbing Wuluh (Averrhoa bilimbi L.). VII(2), 61–67.

Suryono, C., Ningrum, L., & Dewi, T. R. (2018). Uji Kesukaan dan Organoleptik Terhadap 5 Kemasan Dan Produk Kepulauan Seribu Secara Deskriptif. Jurnal Pariwisata, 5(2), 95–106. https://doi.org/10.31311/par.v5i2.3526.

Tamimi, A. A. ., De Queljoe, E., & Siampa, J. P. (2020). Uji Efek Analgesik Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.) Pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Pharmacon, 9(3), 325.

Vania, A. (2020). Evaluasi Nyeri Kepala pada Anak dan Remaja. 47(2), 117–122.

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Published

2024-07-18

How to Cite

Arifina Fahamsya, Endang Istriningsih, & Novita, S. A. (2024). Formulasi Sediaan Gummy Candies Analgetic Kombinasi Ekstrak Daun Pepaya (Carica papaya L.) Dan Daun Kelor (Moringa oleifera lam.). An-Najat, 2(3), 135–149. https://doi.org/10.59841/an-najat.v2i3.1539

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