Literature Review Artikel: Potensi Mitragyna speciosa (Kratom) sebagai Aktivitas Antioksidan, Antidiabetes, Antiinflamasi, dan Antimikroba
DOI:
https://doi.org/10.59841/an-najat.v3i1.2349Keywords:
Mitragyna speciose, Kratom, Antidiabetic, Anti-inflammatory, Antimicrobial, AntioxidantAbstract
Mitragyna speciosa, or kratom, has attracted attention as a potential therapeutic agent in the treatment of various health conditions. This study aimed to evaluate the antioxidant, antidiabetic, anti-inflammatory, and antimicrobial activities of kratom leaf extract. The results showed that kratom extract had high total phenolics, with IC50 values for DPPH and ABTS antioxidant activities of 21.61 µg/mL and 9.33 µg/mL, respectively. In the context of antidiabetic, kratom extract significantly reduced blood glucose levels in a diabetic rat model, and showed positive effects in an oral glucose tolerance test. Anti-inflammatory activity was evaluated through the reduction of pain and inflammation in the animal model, while antimicrobial activity was demonstrated by the inhibition of the growth of pathogenic bacteria, including Salmonella typhi and Bacillus subtilis, with MICs of 6.25 mg/mL and 3.12 mg/mL, respectively. These findings support the potential of Mitragyna speciosa as a multifunctional therapeutic agent, although further studies are needed to understand its mechanisms and applications in clinical treatment.
References
Juanda, E., Andayani, S., & Maftuch, M. (2019). Phytochemical Screening and Antibacterial Activity of Kratom Leaf (Mitragyna speciosa Korth.) Against Aeromonas hydrophilla. The Journal of Experimental Life Sciences, 9(3), 155–158. https://doi.org/10.21776/ub.jels.2019.009.03.02
Parthasarathy, S., Azizi, J. Bin, Ramanathan, S., Ismail, S., Sasidharan, S., Mohd, M. I., & Mansor, S. M. (2009). Evaluation of antioxidant and antibacterial activities of aqueous, methanolic and alkaloid extracts from Mitragyna speciosa (rubiaceae family) leaves. Molecules, 14(10), 3964–3974. https://doi.org/10.3390/molecules14103964
Salim, H. M., Choirotussanijjah, Awwalia, E. S., & Alam, I. P. (2022). Anti-inflammatory effects and potential mechanisms of Mitragyna speciosa methanol extract on λ-karagenan-induced inflammation model. Bali Medical Journal, 11(3), 1172–1175. https://doi.org/10.15562/bmj.v11i3.3535
Shaik Mossadeq, W. M., Sulaiman, M. R., Tengku Mohamad, T. A., Chiong, H. S., Zakaria, Z. A., Jabit, M. L., Baharuldin, M. T. H., & Israf, D. A. (2009). Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract. Medical Principles and Practice, 18(5), 378–384. https://doi.org/10.1159/000226292
Wijayanti, D. K., Masriani, M., Fadly, D., Muharini, R., & Rasmawan, R. (2023). Inhibition of α-Glucosidase Enzyme by Ethanol Extract of Kratom Leaf Variant (Mitragyna speciosa Korth.). Hydrogen: Jurnal Kependidikan Kimia, 11(3), 286. https://doi.org/10.33394/hjkk.v11i3.7776
Yuniarti, R., Nadia, S., Alamanda, A., Zubir, M., Syahputra, R. A., & Nizam, M. (2020). Characterization, Phytochemical Screenings and Antioxidant Activity Test of Kratom Leaf Ethanol Extract (Mitragyna speciosa Korth) Using DPPH Method. Journal of Physics: Conference Series, 1462(1). https://doi.org/10.1088/1742-6596/1462/1/012026
Zhang, P., Wei, W., Zhang, X., Wen, C., Ovatlarnporn, C., & Olatunji, O. J. (2023). Antidiabetic and antioxidant activities of Mitragyna speciosa (kratom) leaf extract in type 2 diabetic rats. Biomedicine and Pharmacotherapy, 162, 114689. https://doi.org/10.1016/j.biopha.2023.114689
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