Gambaran BMI (Body Mass Index) Pasien Kanker Nasofaring Yang Menjalani Terapi IMRT di Unit Radioterapi RSUP Prof. Dr. I.G.N.G Ngoerah
DOI:
https://doi.org/10.59841/an-najat.v1i4.550Keywords:
Nasopharyngeal Cancer, Radiotherapy, IMRT, Body Mass IndexAbstract
One of the cancers that causes the highest mortality is nasopharyngeal cancer. The number of nasopharyngeal cancer cases in Indonesia reached 19,943 new cases with a mortality rate of 13,399. Radiotherapy is the main treatment modality and part of standard care for cancer patients. The way radiotherapy works is to damage the DNA chain of tumor cells in order to kill tumor cells directly and eliminate the ability to proliferate. Giving radiation to the head and neck region has an influence on weight loss. The purpose of this study was to describe the BMI (Body Mass Index) of nasopharyngeal cancer patients who underwent IMRT therapy at the Radiotherapy Unit of Prof. Dr. I.G.N.G Ngoerah Hospital. The type of research used is quantitative research with an observational approach using retrospective data. The samples of this study were 25 patients with nasopharyngeal cancer who underwent IMRT therapy from January to December 2021 at the Radiotherapy Unit of Prof. Dr. I.G.N.G Ngoerah Hospital. The results of this study showed 25 samples of nasopharyngeal cancer patients who underwent IMRT therapy experienced weight loss with an average of 13.01 and BMI with an average of 4.93. Based on the results of the Statistical Test which shows that the p value <0.05 which means there is a decrease in body weight in nasopharyngeal cancer patients undergoing IMRT therapy in the Radiotherapy Unit of Prof. Dr. I.G.N.G Ngoerah Hospital. Of the 25 samples of nasopharyngeal cancer patients who underwent IMRT therapy, there were changes in BMI (Body Mass Index) before irradiation and after irradiation. This is evident from the normality test value and Paired Twhich shows a p value <0.05, meaning that there is a decrease in body weight in nasopharyngeal cancer patients undergoing IMRT therapy.
References
Cheng Z, Nakatsugawa M, Hu C, Robertson SP, Hui X, Moore JA, et al (2018). Evaluation of classification and regression tree (CART) model in weight loss prediction following head and neck cancer radiation therapy. Adv Radiat Oncol [Internet]. 3(3):346–55. Available from: https://doi.org/10.1016/j.adro.2017.11.006
Du T, Xiao J, Qiu Z, Wu K (2019). The effectiveness of intensity-modulated radiation therapy versus 2D-RT for the treatment of nasopharyngeal carcinoma: A systematic review and meta-analysis. PLoS One. 14(7):1–14.
Du Y, Feng R, Chang ET, Yin L, Huang T, Li Y, et al (2023). Body mass index and body shape before treatment and nasopharyngeal carcinoma prognosis : A population-based patient cohort study in southern China. (January):1–12.
Globocan (2020). Cancer Incident in Indonesia. Int Agency Res Cancer [Internet]. 858:1–2. Available from: https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
Guo R, Mao YP, Tang LL, Chen L, Sun Y, Ma J (2019). The evolution of nasopharyngeal carcinoma staging. Br J Radiol. 92(1102).
Lin YH, Chang KP, Lin YS, Chang TS (2015). Evaluation of effect of body mass index and weight loss on survival of patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy. Radiat Oncol [Internet]. 10(1):1–9. Available from: http://dx.doi.org/10.1186/s13014-015-0443-3
Sinaga PE, Jamnasi J, Pasaribu SM, - H (2020). Faktor-Faktor yang Memengaruhi Penurunan Body Mass Index Sebelum dan Sesudah Radioterapi pada Pasien Kanker Kepala Leher. Radioter Onkol Indones. 10(2):36–42.
Susilowati P, Nurmayanti W, Semarang PK (2020). Jurnal Imejing Diagnostik. Hubungan Fraksinasi Terhadap Radiasi Terhadap Body Mass Index Pada Kanker Kepala Leher Di Beberapa Instalasi Onkologi Radiasi. 6:86–90.
Tian Y, Tang L, Yi P, Pan Q, Han Y, Shi Y, et al (2020). MiRNAs in radiotherapy resistance of nasopharyngeal carcinoma. J Cancer. 11(13):3976–85.
T. L. Amir and Y. P. M. Azi (2021). “Pengaruh Indeks Massa Tubuh Terhadap Keseimbangan Postural Dinamis Pada Mahasiswa Universitas Esa Unggul,” J. Fisioter. dan Rehabil., vol. 5, no. 2, pp. 152–157, doi: 10.33660/jfrwhs.v5i2.145.
Tran KB, Lang JJ, Compton K, Xu R, Acheson AR, Henrikson HJ, et al (2022). The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 400(10352):563–91.
