Review: Perbedaan Penggunaan Pelarut Terhadap Nilai Rendemen yang Dihasilkan dengan Berbagai Metode Ekstraksi dalam Proses Ekstraksi

Authors

  • Nur Latipah Sulistiawanti Universitas Muhammadiyah Banjarmasin
  • Hairunnisa Hairunnisa Universitas Muhammadiyah Banjarmasin
  • Niken Widya Ningrum3 Universitas Muhammadiyah Banjarmasin
  • Salma Fitriyanti Universitas Muhammadiyah Banjarmasin

DOI:

https://doi.org/10.59841/an-najat.v3i3.3169

Keywords:

Extraction method, Material-solvent ratio, Polar solvent, Ultrasonic extraction, Yield

Abstract

The extraction process plays a crucial role in isolating bioactive compounds from natural materials. The success of the extraction process is heavily influenced by the type of solvent used and the extraction method applied. This review aims to evaluate the impact of solvents with varying polarities—both polar and non-polar—and compare the efficiency of various extraction techniques, such as Soxhlet extraction, reflux, and Ultrasonic Assisted Extraction (UAE) in obtaining extracts from various medicinal plants. Based on a review of previous studies, polar solvents generally yield higher rendemen compared to non-polar solvents, although non-polar solvents are more effective in selectively extracting non-polar compounds. Therefore, the selection of solvents should be tailored to the type of compound to be extracted to achieve optimal results. The UAE method has been proven to be more efficient than conventional extraction techniques, such as Soxhlet and reflux. The use of ultrasonic waves in UAE enhances solvent penetration into plant cells, resulting in higher yields in a shorter time. Several factors also significantly affect the extraction results, such as the solvent-to-material ratio, extraction time, and temperature. Variations in these three factors can lead to significant differences in both the quantity and quality of the extract obtained. Overall, choosing the right solvent and extraction method is essential for achieving optimal extraction results. By using solvents suited to the properties of the target compounds and selecting the most efficient method, the resulting extracts can be of higher quality and quantity. Therefore, further laboratory research is necessary to apply these findings in developing extraction methods that are not only effective but also environmentally friendly, particularly on an industrial scale. Future research could also focus on developing extraction methods that reduce the use of harmful solvents and enhance the sustainability of the extraction process at an industrial scale.

References

Andika, T., & Putri, O. K. (2018). Hasil maserasi dan sokletasi berdasarkan analisa spektrofotometri UV-Vis. Majalah BIAM, 1-10.

Ayu Susanti, D., Hidayati, S., Firdaus, A. W., Pangesti, D. Y., & Milyunier, F. M. P. (2024). Pengaruh perbedaan metode ekstraksi terhadap uji aktivitas antibakteri ekstrak etanol biji ketumbar (Coriandrum sativum) pada Staphylococcus aureus. Jurnal Farmamedika (Pharmamedica Journal), 9(1), 97-104. https://doi.org/10.47219/ath.v9i1.297

Azizah, A. N., & Marfu, N. (2020). Aktivitas antibakteri ekstrak etanol teh hijau (Camellia sinensis) terhadap pertumbuhan Staphylococcus epidermidis. Pharmaceutical Journal of Islamic Pharmacy, 4(2). https://doi.org/10.21111/pharmasipha.v4i2.4158

Badaring, D. R., Sari, S. P. M., Nurhabiba, S., Wulan, W., & Lembang, S. A. R. (2020). Uji ekstrak daun maja (Aegle marmelos L.) terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Indonesian Journal of Fundamental Sciences, 6(1), 16. https://doi.org/10.26858/ijfs.v6i1.13941

Budiana, W., Anggraeni, V. J., & Wahyudi, A. (2020). Pemanfaatan ekstrak daun dan batang pelawan (Tristaniopsis obovata) sebagai inhibitor enzim alfa glukosidase. Jurnal Farmasi Galenika, 7(3), 165-175. https://doi.org/10.70410/jfg.v7i3.183

Dwi Puspitasari, A., & Syam Proyogo, L. S. (2020). Perbandingan metode ekstraksi maserasi dan sokletasi terhadap kadar flavonoid total ekstrak daun kersen (Muntingia calabura). Jurnal Ilmiah Cendekia Eksakta, 1-8.

Elvansi, M., Vifta, R. L., & Elvansi, M. (2022). Penentuan kadar flavonoid total ekstrak daun rambai laut dengan variasi pelarut ekstraksi (Sonneratia caseolaris L.). Indonesian Journal of Pharmacy and Natural Product, 5(1), 12-18. https://doi.org/10.35473/ijpnp.v5i1.1544

Elya, B., Cahyan Forestrania, R., Hashim, N. M., & Triadisti, N. (2024). Dipeptidyl peptidase-4 inhibition of Peronema canescens Jack leaves and stems: Bioassay-guided fractionation, compound profiling by LC-MS/MS, and interaction mechanism. Journal of Applied Pharmaceutical Science, 14(7), 90-101. https://doi.org/10.7324/JAPS.2024.161007

Faried, M. Y., & Mas, N. (2024). Uji aktivitas antibakteri ekstrak metanol daun jeruk purut (Citrus hystrix D.C.) dengan metode ekstraksi UAE (Ultrasound Assisted Extraction) terhadap bakteri Propionibacterium acnes menggunakan difusi cakram. Journal of Innovation Research and Knowledge, 3(6), 2085-2106.

Fauziyah, R., Widyasanti, A., & Rosalinda, S. (2022). Perbedaan metode ekstraksi terhadap kadar sisa pelarut dan rendemen total ekstrak bunga telang (Clitoria ternatea L.). Kimia Padjadjaran, 1, 18-25. https://jurnal.unpad.ac.id/jukimpad

Firdausia, R. S., Pratama, N. P., Kurniawati, E., Ervany, I., & Irawan, D. (2025). Optimasi waktu ekstraksi dengan metode ultrasound assisted extraction (UAE) terhadap kandungan senyawa flavonoid dan fenolik daun kayu bulan (Pisonia alba Span.). Jurnal Mandala Pharmacon Indonesia (JMPI), 11(1), 274-280. https://doi.org/10.35311/jmpi.v11i1.715

Handayani, F., Apriliana, A., & Ariyanti, L. (2019). Perbandingan metode maserasi dan refluks terhadap rendemen ekstrak daun selutui puka (Tabernaemontana macrocarpa Jack). Jurnal Farmasi Galenika, 6(1), 33-42.

Hasan, H., Thomas, N. A., Taupik, M., & Potabuga, G. (2023). Efek antelmintik ekstrak metanol kulit batang nangka (Artocarpus heterophyllus) terhadap cacing Ascaris lumbricoides. Journal Syifa Sciences and Clinical Research, 4(1), 244-250. https://doi.org/10.37311/jsscr.v4i1.14217

Hidayah, N., Sumandiarsa, I. K., & Alqadiri, W. M. (2024). Screening of phytochemical compounds and antifungal activity of Padina sp. extracted by ultrasound assisted extraction against Aspergillus flavus. Jurnal Pengolahan Hasil Perikanan Indonesia, 27(4), 297-308. https://doi.org/10.17844/jphpi.v27i4.44634

Lalopua, V. M. N. (2020). Rendemen ekstrak kasar dan fraksi pelarut alga merah (Kappaphycus alvarezii Doty). Majalah BIAM, 16(1), 1-5.

Mamonto, S. I., Runtuwene, F., & Wehantouw, M. R. J. (2014). Aktivitas antioksidan ekstrak kulit biji buah pinang yaki (Areca vestiaria Giseke) yang diekstraksi secara soklet. PHARMACON Jurnal Ilmiah Farmasi, 3(3), 263-272.

Kristina, M., Vita, C., Yusasrini, N. L. A., & Yusa, N. M. (2022). Pengaruh waktu ekstraksi dengan menggunakan metode ultrasonic assisted extraction (UAE) terhadap aktivitas antioksidan ekstrak daun duwet (Syzygium cumini). Jurnal Ilmu Dan Teknologi Pangan (ITEPA), 11(1), 13. https://doi.org/10.24843/itepa.2022.v11.i01.p02

Maryam, F., Utami, Y. P., Mus, S., & Rohana, R. (2023). Perbandingan beberapa metode ekstraksi ekstrak etanol daun sawo duren (Chrysophyllum cainito L.) terhadap kadar flavanoid total menggunakan metode spektrofotometri UV-VIS. Jurnal Mandala Pharmacon Indonesia, 9(1), 132-138. https://doi.org/10.35311/jmpi.v9i1.336

Ngo, T. V., Scarlett, C. J., Bowyer, M. C., Ngo, P. D., & Vuong, Q. V. (2017). Impact of different extraction solvents on bioactive compounds and antioxidant capacity from the root of Salacia chinensis L. Journal of Food Quality, 2017. https://doi.org/10.1155/2017/9305047

Pettanaga, P. F., Katja, D. G., & Koleangan, H. S. J. (2024). Aktivitas penghambatan enzim α-amylase oleh ekstrak etanol hasil soxhletasi dan refluks daun manggis (Garcinia mangostana L.). Chemistry Progress, 17(2), 113-122. https://doi.org/10.35799/cp.17.2.2024.56254

Pujiastuti, E., & El'Zeba, D. (2021). Perbandingan kadar flavonoid total ekstrak etanol 70% dan 96% kulit buah naga merah (Hylocereus polyrhizus) dengan spektrofotometri. Cendekia Journal of Pharmacy, 5(1), 28-43. https://doi.org/10.31596/cjp.v5i1.131

Rachma, D. F., Widyasanti, A., & Harnesa, S. (2021). Ekstraksi oleoresin dari kulit mangga kuweni (Mangifera odorata Griff) dengan ultrasound assisted extraction (UAE) bertingkat. Jurnal Keteknikan Pertanian Tropis Dan Biosistem, 9(1), 20-25. https://doi.org/10.21776/ub.jkptb.2021.009.01.03

Rivai, H., Yulion, R., & Krisyanella, D. (2012). Penentuan pengaruh jenis pelarut pengekstrak terhadap perolehan kadar senyawa fenolat dan aktivitas antioksidan dari daun jambu biji (Psidium guajava L.). Jurnal Farmasi Higea, 4(1), 16-23.

Sayuti, M. (2017). Pengaruh perbedaan metode ekstraksi, bagian dan jenis pelarut terhadap rendemen dan aktivitas antioksidan bambu laut (Isis hippuris). Technology Science and Engineering Journal, 1(3), 2549-1601.

Sofihidayati, T., Wardatun, S., & Hidayati, S. (2021). Kajian pengaruh perbedaan metode ekstraksi tangkai bunga cengkeh (Syzygium aromaticum (L) Merr) terhadap kadar eugenol. FITOFARMAKA: Jurnal Ilmiah Farmasi, 11(2), 155-163. https://doi.org/10.33751/jf.v11i2.3057

Irianty, S., Yenti, R. S., & Yenti, S. R. (2014). Pengaruh perbandingan pelarut etanol-air terhadap kadar tanin pada sokletasi daun gambir (Uncaria gambir Roxb.). Sagu, 13(1), 1-7.

Susanty, S., & Bachmid, F. (2016). Perbandingan metode ekstraksi maserasi dan refluks terhadap kadar fenolik dari ekstrak tongkol jagung (Zea mays L.). Jurnal Konversi, 5(2), 87. https://doi.org/10.24853/konversi.5.2.87-92

Tapalina, N., Tutik, T., & Saputri, G. A. R. (2022). Pengaruh metode ekstraksi panas terhadap aktivitas antioksidan ekstrak kulit bawang merah (Allium cepa L.). Jurnal Ilmu Kedokteran Dan Kesehatan, 9(1), 492-500. https://doi.org/10.33024/jikk.v9i1.5830

Triadisti, N., Elya, B., Hanafi, M., Hashim, N. M., & Illahi, A. D. (2025). α-Glucosidase inhibitor compounds of Uncaria sclerophylla leaves' most active chromatography fraction: In vitro, in silico, and ADMET analysis. Journal of Applied Pharmaceutical Science, 15(3), 228-240. https://doi.org/10.7324/JAPS.2025.215871

Ulfah, M. (2023). Potensi antioksidan dan kadar total fenolik flavonoid ekstrak daun pandan wangi (Pandanus amarillyfolius Roxb.) pada variasi pelarut. Media Farmasi Indonesia, 18(2), 115-123. https://doi.org/10.53359/mfi.v18i2.227

Verdiana, M., Widarta, I. W. R., & Permana, I. D. G. M. (2018). Pengaruh jenis pelarut pada ekstraksi menggunakan gelombang ultrasonik terhadap aktivitas antioksidan ekstrak kulit buah lemon (Citrus limon (Linn.) Burm F.). Jurnal Ilmu Dan Teknologi Pangan (ITEPA), 7(4), 213. https://doi.org/10.24843/itepa.2018.v07.i04.p08

Wahyuni, W. T., & Rafi, M. (2017). Metode ekstraksi dan pemisahan optimum untuk isolasi xantorizol dari temulawak (Curcuma xanthorrhiza). Jurnal Jamu Indonesia, 2, 43-50. https://doi.org/10.29244/jji.v2i2.31

Wewengkang, D. S., & Rotinsulu, H. (2021). Potensi ekstrak refluks kulit batang kayu manis (Cinnamomum burmannii) sebagai antijamur Candida albicans dan Candida tropicalis. FITOFARMAKA: Jurnal Ilmiah Farmasi, 11(2), 15. https://doi.org/10.33751/jf.v11i2.2722

Wijaya, A., & Satriawan, B. (2023). Pengaruh perbedaan jenis pelarut terhadap nilai rendemen ekstrak daun pepaya (Carica papaya L.). Jurnal Ilmiah JOPHUS: Journal Of Pharmacy UMUS, 5(1), 10-17. https://doi.org/10.46772/jophus.v5i1.728

Downloads

Published

2025-08-02

How to Cite

Nur Latipah Sulistiawanti, Hairunnisa Hairunnisa, Niken Widya Ningrum3, & Salma Fitriyanti. (2025). Review: Perbedaan Penggunaan Pelarut Terhadap Nilai Rendemen yang Dihasilkan dengan Berbagai Metode Ekstraksi dalam Proses Ekstraksi. An-Najat, 3(3), 213–231. https://doi.org/10.59841/an-najat.v3i3.3169

Similar Articles

You may also start an advanced similarity search for this article.