Potential Of Butterfly Pea Flower (Clitoria Ternatea) Extract As An Antidiabetic Agent: Literature Review
DOI:
https://doi.org/10.59841/an-najat.v3i4.2535Keywords:
butterfly pea flower, clitoria ternatea, diabetes, glucose levelAbstract
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. The global prevalence of diabetes mellitus continues to increase, posing a significant health and economic burden to society. Conventional pharmacological treatments that are currently available often cause unwanted side effects, so alternative therapies that are safer and more effective are needed. This study aims to collect and analyze data related to the effectiveness of flower extract as an antidiabetic agent in reducing blood glucose levels and preventing complications associated with diabetes. The potential of Clitoria ternatea as an antidiabetic agent was explored through a systematic literature review. Article searches were conducted using scientific databases such as Google Scholar, ScienceDirect, and Mendeley with the keywords "Clitoria ternatea AND diabetes AND blood glucose". The inclusion criteria applied included experimental studies conducted on diabetic samples, interventions with bay flower extract administration, and publications within the last 5 years (2021-2025). From a total of 1,858 articles identified, by applying the PRISMA-ScR method, eight articles were obtained that met the inclusion criteria. The results of the analysis showed that flower extract was effective in reducing blood glucose levels in both diabetes-induced experimental animals and diabetic patients. This antidiabetic effect is thought to be due to the flavonoids and other bioactive compounds in butterfly pea flower that act as α-amylase enzyme inhibitors, antioxidants, and anti-inflammatories. These findings indicate the potential of Clitoria ternatea as a promising therapeutic alternative in the management of diabetes mellitus.
References
Besan, E. J., Rahmawati, I., & Saptarini, O. (2023). Aktivitas Antibiofilm Ekstrak dan Fraksi-Fraksi Bunga Telang (Clitoria ternatea Staphylococcus L.) terhadap aureus. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia).
Dewi, I., Chodidjah, C., & Hussaana, A. (2023). Evaluation of Clitoria ternatea L. Flower Extract in Preventing Complications of Diabetes Mellitus. Tropical Journal of Natural Product Research, 7(10), 4908–4911. https://doi.org/10.26538/tjnpr/v7i10.28
Ginting, E. E., Rumanti, R. M., Savira, D., Ginting, P., Marbun, N., & Leny, L. (2022). In Vivo study of Antidiabetic Activity from Ethanol Extract of Clitoria ternatea L. Flower. Journal of Drug Delivery and Therapeutics, 12(6), 4–9. https://doi.org/10.22270/jddt.v12i6.5759
Gunawan, O., Putranto, R. P. A., Subandono, J., & Budiastuti, V. I. (2023). The Effect of Butterfly Pea Extract on Blood Glucose Levels in White Rats with Metabolic Syndrome Model. Smart Medical Journal, 6(1), 14. https://doi.org/10.13057/smj.v6i1.67934
Hardianto, D. (2021). Telaah Komprehensif Diabetes Melitus: Klasifikasi, Gejala, Diagnosis, Pencegahan, Dan Pengobatan. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 7(2), 304–317. https://doi.org/10.29122/jbbi.v7i2.4209
International Diabetes Federation. (2021). IDF Diabetes Atlas 10th Edition. International Diabetes Federation.
Khoirunnisa, A., & Ikaningtyas, M. (2023). Sosialisasi Pengolahan Bunga Telang dan Branding Packaging Bunga Telang Bagi Pelaku UMKM di Kelurahan Japanan, Mojowarno, Jombang. NEAR: Jurnal Pengabdian Kepada Masyarakat, 3(1), 16–21. https://doi.org/10.32877/nr.v3i1.833
Mendrofa, D. S., Zega, A. I., & Karota, E. (2024). EFEKTIVITAS EKSTRAK BUNGA TELANG ( Clitoria ternatea L .) UNTUK MENURUNKAN KADAR GULA DARAH : LITERATURE REVIEW. March. https://doi.org/http://dx.doi.org/10.32419/jppni.v9i1.586
Numsang, P., Oumtanee, A., Kurat, S., Sananok, R., Kraichan, S., & Sarapoke, P. (2023). Failure to control blood sugar experiences of persons with type 2 diabetes mellitus. International Journal of Nursing Sciences, 10, 527-532. doi.org/10.1016/j.ijnss.2023.09.004
Pangondian, A., Rambe, R., Umaya, C., Athaillah, A., & Jambak, K. (2023). POTENSI EKSTRAK BUNGA TELANG (Clitorea ternatea L.) TERHADAP ANTIDIABETES PADA MENCIT PUTIH JANTAN (Mus musculus). Forte Journal, 3(2), 150–157. https://doi.org/10.51771/fj.v3i2.630
Rahmayunita, N. A., Kadriyan, H., & Yuliyani, E. A. (2023). A healthy lifestyle of the diabetic sufferer to avoid the risk of complications: Literature Review. Jurnal Biologi Tropis, 23(2), 406–413. https://doi.org/10.29303/jbt.v23i2.4923
Ridwan, A. M., & Setiawan, G. D. (2023). Perbandingan Berbagai Model Machine Learning Untuk Mendeteksi Diabetes. Teknokom: Jurnal Teknologi Dan Rekayasa Sistem Komputer, 6(2), 127–132. https://doi.org/10.31943/teknokom.v6i2.152
Rosni, R., Lister, I. N. E., Fachrial, E., Ginting, S. F., Widowati, W., & Wahyuni, C. D. (2021). Potential of Gnetum gnemon L. Seed Extract against Insulin Levels and PDX-1 Expression in Diabetes Mellitus Rats Model. EEE International Conference on Health, Instrumentation & Measurement, and Natural Ssciences (InHeNce). https://doi.org/10.1109/InHeNce52833.2021.9537215
Safitri, A., Dirja, M. D. P. A., Puspita, S. R., Kasifah, Khodijah, N. S., Apriliana, R., Oktalia, H., Sari, Y. S., Rahmawati, A., Amelia, T. R., Sari, R. E., Selfiani, T., & Astuti, D. P. (2023). Laporan Penanggungjawaban Terapi Aktivitas Kelompok (Tak) Pada Klien Dengan Diabetes Mellitus Di Wisma Pisang Panti Sosial Tresna Werdha Budi Mulya 2 Jakarta Barat Tahun 2023. Nusantara Hasana Journal, 3(2), 205–208. https://doi.org/10.59003/nhj.v3i2.928
Simangunsong, E. M. V., Febriani, Y., Saputri, M., Arisa, D., & Afifah, G. Z. (2023). Effectiveness Of Butterfly Pea Ethanol Extract On Decreasing Blood Glucose Levels Of Male Mice. JAMBURA JOURNAL OF HEALTH SCIENCE AND RESEARCH, 5(2). https://ejurnal.ung.ac.id/index.php/jjhsr/index
Simatupang, R., & Kristina, M. (2023). Penyuluhan Tentang Diabtes Melitus Pada Lansia Penderita DM. Jurnal Pengabdian Mandiri, 2(3), 849–857.
Sunarti, & Octavini, P. (2023). Efek Antidiabetes Fraksi N-Heksana, Etil Asetat, Dan Air Dari Bunga Telang (Clitoria Ternatea L.) Pada Tikus Jantan yang Diinduksi Streptozotocin-Nikotinamid. Journal of Pharmaceutical and Sciences, 6(2), 400–408. https://doi.org/10.36490/journal-jps.com.v6i2.96
Utami, W., Laksono, Y. D., Setiawibowo, S. N. F., Sunarsih, E. S., Wulandari, F., & Rohana, E. (2024). Antidiabetic and antioxidant activity of Clitoria ternatea flower extracts and fractions on blood glucose and MDA in rats induced by alloxan. Pharmacy Education, 24(6), 21–27. https://doi.org/10.46542/pe.2024.246.2127
Widowati, W., Darsono, L., Lucianus, J., Setiabudi, E., Susang Obeng, S., Stefani, S., Wahyudianingsih, R., Reynaldo Tandibua, K., Gunawan, R., Riski Wijayanti, C., Novianto, A., Sari Widya Kusuma, H., & Rizal, R. (2023). Butterfly pea flower (Clitoria Ternatea L.) extract displayed antidiabetic effects through antioxidant, anti-inflammatory, lower hepatic GSK-3β, and pancreatic glycogen on Diabetes Mellitus and dyslipidemia rat. Journal of King Saud University - Science, 35(4), 102579. doi.org/10.1016/j.jksus.2023.102579
Zilmi, L. R., Weni, L., & Arifandi, F. (2024). Uji Antidiabetes Bunga Telang (Clitoria ternatea) pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Cempaka Putih Jakarta Pusat. Majalah Sainstekes, 11(1), 1–8.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 An-Najat
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
