Kajian Sistematis Efek Empiris, Farmakologis dan Aplikasi Klinis Formula Herbal Sheng Mai San

Authors

  • Aryaprana Nando Universitas Medika Suherman
  • Hari Iskandar Kang Universitas Medika Suherman
  • Fenny Yunita Universitas Tarumanegara
  • Maya Septriana Universitas Airlangga
  • Lismin Dirwanto Sekolah Tinggi Agama Buddha Nalanda
  • Lismin Dirwanto Sekolah Tinggi Agama Buddha Nalanda

DOI:

https://doi.org/10.59841/an-najat.v1i3.151

Keywords:

Sheng Mai San, Sheng Mai Powder, Traditional Chinese Medicine

Abstract

Background: Shengmai Powder or Sheng Mai San (SMS) is a classic traditional Chinese herbal formula for enhancing qi and nourishing yin, and nowadays it is widely used for the treatment of arrhythmia, myocarditis, coronary heart disease, chronic heart failure and other heart diseases. Methods: This article is a systematic review of published evidences about the empirical and pharmacological effects of SMS available from Sciencedirect, PubMed and CNKI data bases. Results: In the classical book of TCM, SMS is stated to have the effect of enhancing Qi and Yin. Nowadays it is widely used to treat arrhythmia, myocarditis, coronary heart disease, heart failure, and others. Many pharmacologic and clinical studies indicate its mechanism and effectiveness for the treatment of those various diseases. Conclusion: The empirical effects of SMS have largely been proven to possess anti-oxidant, anti-inflammatory, metabolic, anti-hypoxia, immune-potentiation, and other effects, and to be effective in treatment of angina pectoris, myocarditis, coronary heart disease, heart failure, arrhythmia, and others.

References

CHEN Jing, YU Zhengke, LI Shanshan & ZHAO Mengxue. (2023). Mechanism of action of Shengmai powder in treatment of viral myocarditis: A study based on network pharmacology. Hunan Journal of Traditional Chinese Medicine (04),158-164+183. doi:10.16808/j.cnki.issn1003-7705.2023.04.036. 陈静,喻正科,李珊珊 & 赵梦雪.(2023).基于网络药理学探讨生脉散治疗病毒性心肌炎的作用机制. 湖南中医杂志(04),158-164+183. doi:10.16808/j.cnki.issn1003-7705.2023.04.036. Mechanism of action of Shengmai powder in treatment of viral myocarditis: A study based on network pharmacology - CNKI

Chen Zhi, Liu Kun, Liu Wei, Yuan Kangrui, Ye Xiaomei, Wu Dudu & Lu Hongmei. (2022). Renoprotection mechanism of Shengmai powder on rats with diabetic nephropathy. Journal of Guangdong Medical University(03),259-262. doi:CNKI:SUN:GDYY.0.2022-03-003. Renoprotection mechanism of Shengmai powder on rats with diabetic nephropathy - CNKI

Gan Decheng, Yang Lixia, Midenghai & Li Mai. (2023). Meta-analysis of Shengmai San(生脉散) in the Treatment of Diabetes Mellitus Complicated with Coronary Heart Disease. Journal of Practical Chinese Internal Medicine (02), 39-42+153-155. doi:10.13729/j.issn.1671-7813.Z20212105. [1]甘德成,杨丽霞,米登海 & 李迈.(2023).生脉散治疗糖尿病合并冠状动脉粥样硬化性心脏病的Meta分析. 实用中医内科杂志(02),39-42+153-155. doi:10.13729/j.issn.1671-7813.Z20212105. Meta-analysis of Shengmai San(生脉散) in the Treatment of Diabetes Mellitus Complicated with Coronary Heart Disease - CNKI

Han Yi, Liu Yong, Jia Yuexia & Zang Hongmin. (2022). Effects of Modified Shengmai Powder on Serum GDF-15 and Soluble ST2 in Patients with Acute Exacerbation of Chronic Heart Failure. Journal of Cardiovascular and Cerebrovascular Diseases of Integrated Traditional Chinese and Western Medicine (05), 893-897. doi:CNKI:SUN:ZYYY.0.2022-05-024. Effects of Modified Shengmai Powder on Serum GDF-15 and Soluble ST2 in Patients with Acute Exacerbation of Chronic Heart Failure - CNKI

Han Yi, Zang Hongmin, Luo Yanli & Du Yongfang. (2022). Effect of modified Shengmai Powder combined with noninvasive ventilation on immune function and oxidative stress injury in patients with acute exacerbation of chronic obstructive pulmonary disease. Hebei Traditional Chinese Medicine(04),564-568+573. doi:CNKI:SUN:HBZY.0.2022-04-009. Effect of modified Shengmai Powder combined with noninvasive ventilation on immune function and oxidative stress injury in patients with acute exacerbation of chronic obstructive pulmonary disease - CNKI

Hao Xiuhua, Zhang Li, Zhao Liying, Du Xiaorong & Yang Jinzhu (2022): Network Pharmacology and Molecule Docking-Based Investigation on the Mechanisms of Action of Shengmai Powder in the Treatment of Diabetes. Specialty Research. doi:10.16720/j.cnki.tcyj.2022.162. [1]郝秀华,张莉,赵丽颖,杜小蓉 & 杨锦竹..基于网络药理学和分子对接技术探讨生脉散治疗糖尿病的作用机制. 特产研究. doi:10.16720/j.cnki.tcyj.2022.162. Network Pharmacology and Molecule Docking-Based Investigation on the Mechanisms of Action of Shengmai Powder in the Treatment of Diabetes - CNKI

HU Jinping, CHEN Liyun & YAN Shiyun. (2023). Protective Effect of Modified Shengmaisan on Cardiac Function in Elderly Patients with Myocardial Infarction Based on NF-κB/iNOS/NO Signaling Pathway. Chinese Journal of Experimental Medical Formulae (03), 110-116. doi:10.13422/j.cnki.syfjx.202202028. Protective Effect of Modified Shengmaisan on Cardiac Function in Elderly Patients with Myocardial Infarction Based on NF-κB/iNOS/NO Signaling Pathway - CNKI

JIANG Yujie, ZHANG Xiangzhuo, ZHANG Shumeng, YU Zixuan, LIU Jia, LI Jie & CHEN Lingli. (2022). Modified Shengmai San Combined Western Medicine Treats Angina Pectoris:A Meta-analysis. World Chinese Medicine (20), 2885-2891. Modified Shengmai San Combined Western Medicine Treats Angina Pectoris:A Meta-analysis - CNKI

Ji YB季宇彬(ed.). Bab 8, Formula Tonik (Bu Yi Fang). Di dalam: Farmakologi formula herbal dan aplikasinya 复方中药药理与应用(chn). China Medical Science Publisher中国医药科技出版社, Beijing. 2005, pp.445-462. ISBN 7506732106/R2670.

Li Yanqiu & Cui Wenwang. (2023). Effect of Yuquan Pills combined with Shengmai Powders on type 2 diabetes mellitus with the syndrome of deficiency of both qi and yin and its influence on the major cardiovascular risk factors. Jilin Traditional Chinese Medicine(03),304-307. doi:10.13463/j.cnki.jlzyy.2023.03.014. 李艳秋 & 崔文旺.(2023).玉泉丸合生脉散对气阴两虚证2型糖尿病临床疗效及心血管主要危险因素的影响. 吉林中医药(03),304-307. doi:10.13463/j.cnki.jlzyy.2023.03.014. Effect of Yuquan Pills combined with Shengmai Powders on type 2 diabetes mellitus with the syndrome of deficiency of both qi and yin and its influence on the major cardiovascular risk factors - CNKI

Li Yingying, Wang Xin & Wang Furong. (2022). Analysis of Shengmai Powder in the Treatment of Diabetic Cardiomyopathy. World Science and Technology-Modernization of Traditional Chinese Medicine(04),1509-1514. Analysis of Shengmai Powder in the Treatment of Diabetic Cardiomyopathy - CNKI

Liu Chunhua, Feng YQ, Zhou DZ, et al (2022). Sheng-Mai San extracts attenuate heart injury in chronic intermittent hypoxia via suppressing oxidative damage and regulating glucose metabolism, Pharmacological Research - Modern Chinese Medicine, Volume 5, 2022, 100194, ISSN 2667-1425, https://doi.org/10.1016/j.prmcm.2022.100194. (https://www.sciencedirect.com/science/article/pii/S2667142522001531).

Lou Qianying, Cao Cheng, Wang Qingqing, et al (2022). Network Pharmacological Analysis of the Mechanism of Kai-Xin-San and Sheng-Mai-San Against Alzheimer’s Disease with "Same Disease with Different Treatments" and Effect Verification of Central Nervous Inflammation Regulation. World Science and Technology-Modernization of Traditional Chinese Medicine(01),98-112. Network Pharmacological Analysis of the Mechanism of Kai-Xin-San and Sheng-Mai-San Against Alzheimer’s Disease with "Same Disease with Different Treatments" and Effect Verification of Central Nervous Inflammation Regulation - CNKI

Wang Li. (2022). Protective Effect of Shengmai San on Radiation-induced Hematopoietic System Injury (Master's thesis, Yangtze University). 王莉.(2022).生脉散对辐射致造血系统损伤的保护作用(硕士学位论文,长江大学). https://kns.cnki.net/KCMS/detail/detail.aspx?dbname=CMFDTEMP&filename=1023410967.nh Protective Effect of Shengmai San on Radiation-induced Hematopoietic System Injury - CNKI

WANG Shuai, WAN Xiaogang, WU Yonggang, CHEN Renshan, YAO Haihun, XIAO Caihong & YI Zhibiao. (2022). Clinical observation of Jiawei Shengmai San in the treatment of septic shock with acute kidney injury. Journal of Guangdong Pharmaceutical University(05),110-113. doi:10.16809/j.cnki.2096-3653.2022051001. 王帅,万晓刚,吴永刚,陈仁山,姚海魂,肖彩宏 & 易智彪.(2022).加味生脉散治疗脓毒性休克合并急性肾损伤的临床观察. 广东药科大学学报(05),110-113. doi:10.16809/j.cnki.2096-3653.2022051001. Clinical observation of Jiawei Shengmai San in the treatment of septic shock with acute kidney injury - CNKI

Wang Ting, Dong Min & Ma Jun. (2023). Effects of Pulse Scattering Plus and Subtraction on Cellular Immune Function and Cytokines in Postoperative Radiotherapy Patients with Qi Deficiency Yin Deficit Breast Cancer: Clinical Data of 73 Cases. Jiangsu Traditional Chinese Medicine(04),40-43. doi:10.19844/j.cnki.1672-397X.2023.04.011. [1]王婷,董敏 & 马珺.(2023).生脉散加减对气虚阴亏型乳腺癌术后放疗患者细胞免疫功能及细胞因子的影响——附73例临床资料. 江苏中医药(04),40-43. doi:10.19844/j.cnki.1672-397X.2023.04.011. 生脉散加减对气虚阴亏型乳腺癌术后放疗患者细胞免疫功能及细胞因子的影响——附73例临床资料 - CNKI

Wang Zhe. (2022). Observation on the Clinical Efficacy of Shengmai Powder in the Treatment of Ventricular Premature Beat(Qi-Yin Deficiency Syndrome) (Master's thesis, Heilongjiang University of Chinese Medicine). Observation on the Clinical Efficacy of Shengmai Powder in the Treatment of Ventricular Premature Beat(Qi-Yin Deficiency Syndrome) - CNKI; https://kns.cnki.net/KCMS/detail/detail.aspx?dbname=CMFD202301&filename=1022677607.nh

Wiki8 (2020). Sheng Mai San. Available from: 生脉散_生脉散的组成、功效、方解、适应证、药理作用、用法用量_医学百科 (wiki8.com)

ZHANG Jinling, ZHUANG Xin & YANG Jie. (2021). Modified Shengmai powder in the treatment of young and middle-aged premature beat. Clinical Research of Traditional Chinese Medicine(33),56-57. doi:CNKI:SUN:ZYLY.0.2021-33-017. 张金玲,庄欣 & 杨洁.(2021).生脉散加减治疗中青年期前收缩. 中医临床研究(33),56-57. doi:CNKI:SUN:ZYLY.0.2021-33-017. Modified Shengmai powder in the treatment of young and middle-aged premature beat - CNKI

Zhang Qingfang & Wang Yisheng. (2022). The Investigation on the Clinical Efficacy and Safety of Jiawei Shengmaisan in the Auxiliary Treatment of Elderly Chronic Pulmonary Heart Disease Complicated with Heart Failure. Journal of Mathematical Medicine (04), 585-587. doi:CNKI:SUN:SLYY.0.2022-04-037. The Investigation on the Clinical Efficacy and Safety of Jiawei Shengmaisan in the Auxiliary Treatment of Elderly Chronic Pulmonary Heart Disease Complicated with Heart Failure - CNKI

Zhang, Xn., Li, Yy., Zhang, Yh. et al (2022). Shengmai San for Treatment of Cardiotoxicity from Anthracyclines: A Systematic Review and Meta-Analysis. Chin. J. Integr. Med. 28, 374–383 (2022). https://doi.org/10.1007/s11655-022-2884-5

Zhang Xiaosong, Jia Yaqian, Yuan Ziwen, et al (2022). Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process, Phytomedicine, Volume 97, 2022, 153920, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2021.153920. (https://www.sciencedirect.com/science/article/pii/S0944711321004608)

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Published

2023-07-26

How to Cite

Aryaprana Nando, Hari Iskandar Kang, Fenny Yunita, Maya Septriana, Lismin Dirwanto, & Lismin Dirwanto. (2023). Kajian Sistematis Efek Empiris, Farmakologis dan Aplikasi Klinis Formula Herbal Sheng Mai San. An-Najat, 1(3), 85–99. https://doi.org/10.59841/an-najat.v1i3.151

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